Multiplexed AMR biosensor using antifouling nanostructured materials based on colloidal quantum dots and SERS
Supervisors
Katrina Campbell, School of Biological Sciences, Queen’s University
Nicolas Laurand, Institute of Photonics, Physics, University of Strathclyde
Summary
AMR (antimicrobial resistance) is very crucial to address, as the interconnected global challenges of microbial contamination and AMR have been projected to cause 50 million deaths by the year 2050 due to drug-resistant infections[1], [2]. Rapid and accurate detection of AMR biomarkers is essential to initiate a timely detection, improve patient outcomes, and reduce health burdens. Conventional techniques like ELISA, PCR, and culture-based methods, though efficient, require trained personnel, are time-consuming, and lack real-time diagnostic capability in real time and especially in resource-limited settings[3], [4].
To overcome these challenges, basic and state-of-the-art biosensor technologies have gained attention particularly following on from COVID. The use of novel nanomaterials for biosensing is also being investigated. The aim of this project is to engineer a next-gen biosensing state-of-the-art platform capable of multiplexed AMR detection in complex samples using antifouling nanostructured materials based on quantum dots and plasmonic particles. Training will be provided in systematic literature reviews, bioinformatics for biomarker selection and characterisation, nanomaterial synthesis and visual and chemical characterisation, biosensor development and validation methodologies in terms of being fit for purpose for field of use and performance characteristics as well as additional skills in project management and those offered by the DTP training.